We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
Read More
8
EPA lowers heart rhythm problems
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We investigated how eicosapentaenoic acid (EPA) affects heart rhythm, particularly in the context of high-fat diets. In our study, mice were divided into two groups: one received a high-fat diet, while the other’s diet was supplemented with EPA for eight weeks.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
Read More
9
High-dose omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Read More
Most Useful Reviews
9
Heart health improvement
16 people found this helpful
The most beneficial concentrated Omega! This Omega is affordable and offers 1000 mg of omega 3, which is recommended for optimal health maintenance. Due to its high concentration of 900 mg in one capsule, it's easier to take regularly, crucial for managing heart disease.
Read More
9
Heart disease management
5 people found this helpful
The quality of omega 3 is indisputable. After extensive testing, I can confirm that it is excellent for heart disease and inflammation. It's safe for all ages and does not raise cholesterol levels. I highly recommend it!
Read More
9
Cholesterol reduction
4 people found this helpful
After researching, I found this has the best quality omega-3s with purity guaranteed. I take it for heart disease and inflammation benefits, and thankfully, there are no stinky burps due to its coating. It is slightly big but worth it!
We analyzed the impact of different fatty acid-derived acylcarnitines on heart health. The study found that saturated and monounsaturated acylcarnitines, especially trans-elaidoylcarnitine, significantly impaired heart function and mitochondrial activity, leading to cardiotoxicity.
In contrast, omega-3-derived acylcarnitines, like eicosapentaenoylcarnitine and docosahexaenoylcarnitine, were found to be safe, having little to no negative effect on heart function and cell viability. Overall, this research suggests that omega-3 fatty acids may be a safer option for those facing cardiac challenges.
Read More
9
High-dose omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Read More
9
Omega-3 reduces heart disease risk
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
Read More
9
Omega-3 benefits African Americans’ heart health
Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation.
We observed that the role of omega-3 fatty acids in heart health showed promising results specifically for African Americans. By comparing matched groups from the VITAL trial, we found that omega-3 supplementation significantly reduced the risk of myocardial infarction in African Americans, while no such benefit was seen in non-Hispanic whites.
This suggests that genetic or lifestyle factors may influence the effectiveness of these supplements. Our findings highlight the importance of further research to better understand how race affects responses to omega-3 supplementation.
Read More
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
The most beneficial concentrated Omega! This Omega is affordable and offers 1000 mg of omega 3, which is recommended for optimal health maintenance. Due to its high concentration of 900 mg in one capsule, it's easier to take regularly, crucial for managing heart disease.
Read More
9
Heart disease management
5 people found this helpful
The quality of omega 3 is indisputable. After extensive testing, I can confirm that it is excellent for heart disease and inflammation. It's safe for all ages and does not raise cholesterol levels. I highly recommend it!
Read More
9
Cholesterol reduction
4 people found this helpful
After researching, I found this has the best quality omega-3s with purity guaranteed. I take it for heart disease and inflammation benefits, and thankfully, there are no stinky burps due to its coating. It is slightly big but worth it!
Read More
9
Improved health
3 people found this helpful
The product is excellent, with significant health improvement noticed. I have better concentration and no side effects when I take it daily. It positively impacts heart health and reduces cholesterol levels; I recommend it to everyone.
Read More
9
Healthy heart support
3 people found this helpful
This product’s quality is outstanding, with effective benefits noticed for hair and skin. I'm very satisfied as my heart health improves, and cholesterol levels normalise. It's only one pill a day, making it convenient.
Heart disease refers to a range of conditions that affect the heart's function and overall health. This umbrella term includes various cardiovascular issues such as coronary artery disease, which is caused by the buildup of plaque in the arteries; heart rhythm problems (arrhythmias); and heart defects present at birth (congenital heart defects). Additionally, heart disease encompasses conditions related to the heart muscle, such as cardiomyopathy, and the heart's valves, which might not open or close properly. The effects of heart disease can be significant, impacting not only physical health but also quality of life, making prevention and timely medical intervention crucial.
Several risk factors contribute to the development of heart disease, including high blood pressure, high cholesterol levels, diabetes, obesity, poor diet, physical inactivity, and smoking. Genetics also play a role, as heart disease can run in families. To mitigate the risks, healthcare professionals typically recommend lifestyle changes such as adopting a heart-healthy diet, engaging in regular physical activity, and avoiding tobacco use. For those already diagnosed with heart disease, treatment options can vary widely, ranging from lifestyle modifications to medications and, in severe cases, surgical interventions. Understanding the nature of heart disease and its risk factors is an essential step toward prevention and effective management.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has long been touted for its potential heart health benefits, and there is a growing body of research that supports its positive role in cardiovascular health. Omega-3 fatty acids—primarily EPA and DHA, found in fish oil—are known to help reduce inflammation, lower triglyceride levels, and may improve arterial function. Studies suggest that regular consumption of omega-3s can lead to a modest reduction in the risk of heart disease, particularly for those with existing cardiovascular conditions or elevated risk factors.
However, it's essential to note that while omega-3 fish oil can be beneficial, it should not be seen as a standalone treatment for heart disease. It's most effective when used in conjunction with a heart-healthy lifestyle, which includes a balanced diet, regular exercise, and other preventative measures. As always, it's recommended to consult with a healthcare professional before starting any new supplement regimen, especially for individuals with existing health issues or those on medication. Keep in mind that the effectiveness can vary from person to person, depending on individual health profiles and dietary needs.
Based on user reviews, it appears that individuals taking this omega-3 supplement for heart disease typically start to notice benefits within a few weeks to a couple of months. For example, one user reported significant health improvements and better concentration after daily use, suggesting that consistent intake can lead to noticeable changes relatively quickly Read Review. Others have mentioned improvements in cholesterol levels and overall heart function, which imply that the results may become evident within a similar timeframe Read Review.
Furthermore, many users highlight the importance of regular consumption, with some mentioning that daily intake helps in maintaining heart health and preventing complications related to heart disease Read Review. Consistency with the dosage not only maximizes the benefits but is also deemed crucial for observing meaningful results over time.
Numerous studies support the potential benefits of omega-3 fatty acids in promoting heart health, particularly through their impact on various cardiovascular conditions. Research indicates that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two noteworthy types of omega-3 fatty acids, can reduce the risk of heart diseases like coronary heart disease (CHD) and heart failure [17]. A systematic review has shown that higher omega-3 levels are consistently associated with a lower risk of cardiovascular events, reinforcing their role in heart health [27].
In clinical settings, omega-3 supplementation has also demonstrated the ability to improve heart function and reduce life-threatening cardiac events. For instance, a study focusing on patients with elevated triglycerides observed fewer cardiovascular occurrences in those taking icosapent ethyl, a formulation of EPA, compared to those who received a placebo [5]. Although some studies indicate mixed results, particularly regarding the influence of omega-3 on arrhythmias, there is a strong body of evidence that supports the cardiovascular benefits of diet enriched in omega-3 fatty acids [7]. Overall, approaching heart health with omega-3 supplementation seems promising, depending on individual health contexts.
Users report a wide range of improvements in their symptoms after taking this omega-3 supplement, with many highlighting significant benefits for heart health and cholesterol levels. Some individuals noted a drop in harmful cholesterol levels and an overall enhancement in heart function, with one user stating they've experienced better concentration and no side effects from daily use Read Review. Others have also remarked on the product's role in normalizing cholesterol levels while improving overall heart health Read Review.
Additionally, there are testimonials indicating that regular use has helped reduce inflammation and even provided benefits for hair and skin health Read Review. A user specifically mentioned enhancements in brain function alongside heart health, emphasizing that these benefits extend to various aspects of wellbeing Read Review. While these anecdotal experiences are promising, it's important to note that individual results can vary based on personal health conditions and lifestyle factors.
Users report that combining the omega-3 supplement with other health practices or supplements generally enhances its effectiveness in managing heart disease. Many individuals noted that regular intake of this product not only supported heart health but also aided in reducing cholesterol levels, showing a comprehensive improvement in their cardiovascular condition Read Review. Some users even linked their positive experiences with quality of life improvements, suggesting that integrating this supplement into a broader health regimen yields better results Read Review.
Furthermore, the supplement is often praised for its benefits in conjunction with maintaining a balanced diet or combining it with other health supplements. For instance, users have reported an overall reduction in inflammation and improvements in cholesterol levels, which are critical for individuals aiming to combat heart disease Read Review. This underscores the product's versatility and efficacy, encouraging families to adopt it as part of their daily health maintenance strategies, thus leveraging its full potential in conjunction with their standard dietary practices Read Review.
According to recent research, the optimal dose of Omega-3 fish oil, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for effectively managing heart disease appears to fall between 2000 to 4000 mg daily. A comprehensive analysis identified that this range, taken consistently over a year, is significantly associated with improved heart function, notably enhancements in metrics like left ventricular ejection fraction and peak oxygen consumption [6]. Moreover, participants in studies have reported positive changes in various cardiometabolic risk factors, supporting the notion that high-dose Omega-3 supplementation can be a viable adjunct therapy in heart disease management [4].
It's important to note that these benefits were observed with long-term supplementation, as shorter durations or lower doses did not yield the same favorable outcomes. This reinforces the recommendation for a sustained intake at higher doses for those dealing with heart issues [4]. For patients already on statins or experiencing specific cardiovascular events, formulations like icosapent ethyl have demonstrated significant benefits, regardless of base cholesterol levels, further highlighting the versatility and importance of Omega-3 supplementation tailored to individual health conditions [5].
9
Improved health
3 people found this helpful
The product is excellent, with significant health improvement noticed. I have better concentration and no side effects when I take it daily. It positively impacts heart health and reduces cholesterol levels; I recommend it to everyone.
9
Visible health effects
2 people found this helpful
The best omega I've used! The quality is remarkable, and I've experienced a drop in cholesterol. My heart functions well, and I noticed shiny hair. The rapid delivery and packaging were also impressive. Highly recommend!
9
Reduced heart disease risk
1 people found this helpful
Research shows that increased fish oil intake may reduce cardiovascular disease risks. This product effectively lowers triglyceride levels, supporting heart health and reducing the risk of heart disease. The quality is exceptional.
9
Healthy heart support
3 people found this helpful
This product’s quality is outstanding, with effective benefits noticed for hair and skin. I'm very satisfied as my heart health improves, and cholesterol levels normalise. It's only one pill a day, making it convenient.
9
Reduces cholesterol
The quality is remarkable, with effective ingredients that last. This Omega-3 fish oil reduces cholesterol and is beneficial for both hair and arthritis, promoting heart health without an unpleasant taste.
7.5
Comprehensive health benefits
1 people found this helpful
We regularly take omega-3 for its numerous benefits, including improved brain and heart function and reduced inflammation. This product has excellent natural ingredients and is suitable for all ages, benefiting my family and enhancing our overall health.
9
Supports heart health
This quality Omega-3 fish oil supplement is fantastic, especially for older adults. It supports heart, brain, and hair health, and helps reduce inflammation and cholesterol. I regularly take it to lower my cardiovascular disease risk.
8
Normal cholesterol maintenance
3 people found this helpful
Our family takes this Omega regularly due to the difficulty of obtaining quality fats locally. The product is certified, powerful, and allows us to maintain healthy cholesterol levels while supporting heart and brain health.
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
4
CAC progression in diabetic patients
The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial.
We explored the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the progression of coronary artery calcium (CAC) in individuals with heart disease. In a randomized trial involving 242 subjects already on statin therapy, half received daily doses of both EPA and DHA, while the other half did not receive these supplements.
Our findings indicated a notable interaction between diabetes status and the effects of these supplements. Specifically, subjects with diabetes who took EPA and DHA experienced a greater increase in CAC scores compared to those with diabetes in the control group. This suggests that for individuals with diabetes, the use of these omega-3 fatty acids might not be beneficial, as they witnessed significant progression in heart disease markers over a 30-month period.
Meanwhile, we observed no significant difference in CAC progression between the treatment and control groups among those without diabetes. This raises questions about the complex role of EPA and DHA in heart health, particularly in the context of diabetes. Further research is needed to clarify whether this CAC progression indicates worsening disease or if it reflects a stabilization of existing plaques.
8
Omega-3 reduces heart disease risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We explored the effectiveness of icosapent ethyl, a form of omega-3 fish oil, in lowering heart disease rates among high-risk patients with varying cholesterol levels.
In a clinical trial with statin-treated individuals who had elevated triglycerides, it was found that those taking icosapent ethyl experienced significantly fewer cardiovascular events compared to those on a placebo.
Notably, this benefit was seen regardless of their baseline low-density lipoprotein cholesterol (LDL-C) levels, indicating positive outcomes even for patients with well-controlled cholesterol.
7
Omega-3 may reduce certain arrhythmias
The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial.
We conducted a randomized clinical trial with 74 patients recovering from acute coronary syndrome (ACS) to see if Omega-3 supplementation could help reduce harmful heart rhythms. Participants received either a daily dose of 1 gram of Omega-3 or a placebo for five days, with their heart rhythms closely monitored using ECGs.
Our findings showed that Omega-3 fatty acids could potentially help manage arrhythmias, especially atrial fibrillation and some types of contractions. However, the treatment had minimal impact on more severe arrhythmias like ventricular tachycardia and fibrillation, indicating that more research is needed in this area.
9
High-dose omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
8
Diet and fish oil improve heart health
Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study.
We examined the effects of dietary changes, specifically through the MoKaRi study, to see how they influence heart health. Over 20 weeks, 65 participants followed personalized menu plans and received nutritional counselling.
The results were promising, showing notable reductions in various cardiometabolic risk factors. Adding fish oil supplements to these diets further enhanced the benefits, leading to better reductions in body weight, triglycerides, and blood sugar levels.
Overall, our findings suggest that combining a structured diet with fish oil can meaningfully improve heart health.
References
Liepinsh E, Gukalova B, Krims-Davis K, Kuka J, Leduskrasta A, et al. EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines. Biofactors. 2025;51:e70014. 10.1002/biof.70014
Xu J, Peng T, Kong L, Wei N. A global analysis of the burden of ischemic heart disease attributable to diet low in ω-3 fatty acids between 1990 and 2021. BMC Cardiovasc Disord. 2025;25:188. 10.1186/s12872-025-04620-z
Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. 10.1016/j.jphyss.2025.100014
Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. 10.1186/s12944-025-02500-1
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. 10.1515/jcim-2024-0427
Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. 10.1016/j.foodchem.2024.142498
Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. 10.1016/j.mayocp.2024.08.007
Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
Ryuno Y, Kobayashi JI, Fujimoto Y, Dotare T, Matsue Y, et al. Effect of an Enteral Formula Enriched With ω-3 Fatty Acids, Carnitine, and Vitamin D on Body Weight, Heart Weight, and Blood Biochemical Parameters in a Dahl Rat Heart Failure Model. J Cardiovasc Pharmacol. 2024;84:590. 10.1097/FJC.0000000000001637
Sun S, Hara A, Johnstone L, Hallmark B, Watkins JC, et al. Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation. Nutrients. 2024;16. 10.3390/nu16172933
Ahmadi M, Askari VR, Shahri B, Mousavi Noghab SM, Jarahi L, et al. Omega-3 fatty acids effectively mitigate high-sensitivity C-reactive protein (hs-CRP) biomarker of inflammation in acute myocardial infarction patients: a randomized, double-blind, placebo-controlled clinical trial. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:881. 10.1007/s00210-024-03330-1
Chen HC, Tai CJ, Huang JY, Kuo TA, Huang YD, et al. Associations of fish oil with cardiovascular disease events: results from the Taiwan longitudinal study in aging. BMC Public Health. 2024;24:1979. 10.1186/s12889-024-19512-8
Yu Y, Gao M, Xu H. Ginger Extract and Omega-3 Fatty Acids Supplementation: A Promising Strategy to Improve Diabetic Cardiomyopathy. Physiol Res. 2024;73:351.
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.028
Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. 10.1007/s40261-024-01417-4
Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. 10.3390/jcm14010026
Capece U, Gugliandolo S, Morciano C, Avolio A, Splendore A, et al. Erythrocyte Membrane Fluidity and Omega-3 Fatty Acid Intake: Current Outlook and Perspectives for a Novel, Nutritionally Modifiable Cardiovascular Risk Factor. Nutrients. 2024;16. 10.3390/nu16244318
Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. 10.7759/cureus.73417
O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. 10.1016/j.pcad.2024.11.003
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
Amangurbanova M, Daher R, Asbeutah AA, Vemuri B, Mirza H, et al. Higher epicardial adipose tissue volume is associated with higher coronary fatty plaque volume and is regulated by waist circumference but not EPA+DHA supplementation. J Clin Lipidol. 2024;18:e773. 10.1016/j.jacl.2024.06.006
Kumakura H, Funada R, Matsuo Y, Iwasaki T, Nakashima K, et al. Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease. Ann Vasc Dis. 2024;17:135. 10.3400/avd.oa.23-00079
Xiao Y, Chen Y, Pietzner A, Elbelt U, Fan Z, et al. Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies. Nutrients. 2024;16. 10.3390/nu16111610
Asbeutah AA, Daher R, Malik A, Hariri E, Alfaddagh A, et al. The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial. Am J Cardiol. 2024;225:98. 10.1016/j.amjcard.2024.06.001
Sudo Y, Morimoto T, Tsushima R, Oka A, Sogo M, et al. Eicosapentaenoic Acid and the Outcomes in Older Patients Undergoing Atrial Fibrillation Ablation. J Am Heart Assoc. 2024;13:e033969. 10.1161/JAHA.123.033969
Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150:425. 10.1161/CIRCULATIONAHA.123.065520
Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. 10.1093/eurjpc/zwae315
Lv L, Guo Y, Zheng Z, Li B. Blood metabolites mediate effects of breakfast skipping on heart failure via Mendelian randomization analysis. Sci Rep. 2024;14:18957. 10.1038/s41598-024-69874-7
Wang Y, Yang B, Wang C. The association between fatty acids and atherosclerotic diseases: A mendelian randomization study. Clin Nutr ESPEN. 2024;63:447. 10.1016/j.clnesp.2024.06.018
Tian S, Guo T, Qian F, Qiu Z, Lu Q, et al. Fish Oil, Plasma n-3 PUFAs, and Risk of Macro- and Microvascular Complications among Individuals with Type 2 Diabetes. J Clin Endocrinol Metab. 2024. 10.1210/clinem/dgae482
Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. 10.1093/eurjpc/zwae184
Braun TS, Drobner T, Kipp K, Kiehntopf M, Schlattmann P, et al. Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes-The MoKaRi II Randomized Controlled Study. Nutrients. 2024;16. 10.3390/nu16091261
O'Keefe EL, O'Keefe JH, Tintle NL, Westra J, Albuisson L, et al. Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality. Mayo Clin Proc. 2024;99:534. 10.1016/j.mayocp.2023.11.026
Zeinalabedini M, Ladaninezhad M, Mobarakeh KA, Hoshiar-Rad A, Shekari S, et al. Association of dietary fats with ischemic heart disease (IHD): a case-control study. J Health Popul Nutr. 2024;43:19. 10.1186/s41043-023-00489-w
Rennemo J, Berge K, Yousaf MN, Eriksen TB, Welde E, et al. An Atypical Course of Cardiomyopathy Syndrome (CMS) in Farmed Atlantic Salmon () Fed a Clinical Nutrition Diet. Microorganisms. 2023;12. 10.3390/microorganisms12010026